Alzheimer's Drug Exhibits Promise In Early Trial

The results are to be offered Wednesday at the annual assembly of the Alzheimer's Affiliation in Vancouver. The research involved 409 patients with mild to average Alzheimer's disease who were either being handled with the drugs donepezil (Aricept) or rivastigmine (Exelon) or were receiving no remedy. Through the six-month, section 2 trial, patients took both a placebo or one in every of three completely different doses of EVP-6124. After 23 weeks of remedy, the patients in the excessive-dose group confirmed statistically important benefits on tests of mental function compared to those taking the dummy pill. Some patients within the medium- and excessive-dose teams did expertise mild to average gastrointestinal unintended effects, the crew added. Dr. Dana Hilt, senior vice president of clinical development and chief medical officer of EnVivo, mentioned in an Alzheimer's Affiliation information launch. The authors explain that EVP-6124 belongs to a household of medicine called alpha-7 nicotinic agonists, which amplify the results of acetylcholine, a brain chemical that is important for regular mind and reminiscence function.

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